Correlation analysis of the level of high sensitivity C reactive protein, D-dimer and carotid atherosclerotic plaque in patients with acute cerebral infarction

Abstract

Objective To explore the treatment and diagnostic value of combined detection of high sensitivity C reactive protein(hs-CRP) and D-dimer(DD) levels for carotid artery plaque(CAS) in patients with acute cerebral infarction(ACI). Methods 48 patients with ACI were selected as the observation group, while 48 healthy people who excluded ACI were selected as the control group.The vascular ultrasonography and serum levels of hs-CRP and DD were detected within 3 days, and the observation group was classified according to TOAST. Results The hs-CRP and DD levels in the observation group were (7.88±2.54)mg/L and (1 286.2±233.4)μg/L, respectively, which were significantly higher than (1.14±0.32)mg/L and (462.8±147.2)μg/L in the control group (t=15.53, 20.67, all P 0.05). The hs-CRP level was positively correlated with the number of instability carotid plaque(r=0.465, P=0.000), and DD level had no significant correlation with the number of instability carotid plaque. Conclusion Elevated serum hs-CRP and DD levels in ACI patients confirmed its participation in the acute inflammatory response, and hs-CRP can better reflect the instability of ACI patients with CAS. Key words: C-Reactive protein; D-dimmer; Cerebral infarction; Carotid atherosclerotic plaques