Abstract
Objective To evaluate the clinical effect of navelbine and concurrent three-dimensional eonformal radiation therapy (3 D-CRT)for locally advanced non-small cell lung cancer(NSCLC). Methods Ac-cording to the different grades and eharaeteristie of organism of NSCLC,we treated 42 NSCLC patients by 3D-CRT combined with chemotherapy of navelbine and eisplatin. Other 42 patients were treated by chemotherapy and sequential 3D-CRT(as control group). Results In therapy group, the overall response rate(CR+PR)was 86.1% and one-year survival rate was 73.8%. In control group, the overall response rate (CR+PR) and one-year survival rate wero 51.9% and 35.7 % respectively. The difference shows signilieant (P<0.05). Conclusion Concurrent application of novelbine and 3D-CRT can improve the overall response rate for locally advanced NSCLC without aggravating toxicity. Key words: Navelbine; Three-dimensional conformal radiotherapy; Concurrent chemoradiotherapy; Non-small cell lung cancer
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