Abstract
Most human malignant tissues express tumor antigens. Mechanisms whereby molecules that can act as tumor antigens may appear on the cell surface and make them autoantigenic have been proposed by Cochran (1978). It was proposed that neoantigens on tumor cells may appear by (1) reexpression of repressed molecules, (2) modification of existing molecules, (3) uncovering of masked molecules, and (4) deletion of existing molecules. There are many reports in the literature regarding the existence of certain tumor antigens that are immunogenic in the autologous and allogenic host. Though the biological and chemical natures of many of these antigens are not completely known, they are recognized as tumor-associated antigens (TAA). Humoral immune responses to TAA in melanoma patients have been summarized in recent reviews (Aryan, 1979; Old, 1981; Reisfeld and Ferrone, 1982).KeywordsImmune ComplexTumor BurdenTumor AntigenMelanoma PatientRaji CellThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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