Blocking (suppressor) factors, immune complexes, and extracorporeal immunoadsorption in tumor immunity.

Abstract

Some animal neoplasms, particularly many of those induced by chemical carcinogens, have tumor-specific transplantation antigens. These are detected by their ability to induce the rejection of tumors grafted onto properly immunized syngeneic hosts (Prehn and Main, 1957; Old and Boyse, 1964; Sjogren, 1965; K. E. Hellstrom and Brown, 1979), and the tumors expressing the antigens are commonly referred to as immunogenic. It is being debated whether “spontaneous” tumors, like most human tumors, have antigens that can be immunogenic in the native host (Klein and Klein, 1977; Hewitt et al., 1976; Hellstrom et al., 1983).