Clinical observation on Verapamil combined Metformin to treat hypertensive patients with Type 2 Diabetes Mellitus for decompression and regulates blood sugar level

Abstract

Objective To observe blood pressure lowering effect and the blood glucose lowering effect on the combination of Verapamil and Metformin therapy for hypertensive patients with type 2 diabetes mellitus (diabetes mellitus, DM). Methods 129 cases of hypertension in patients with type 2 DM were divided into two groups, Verapamil treatment group, 98 cases in the control group 31 cases. (1) Verapamil treatment groups: Verapamil hydrochloride sustained-release capsules 180 mg/d, Metformin 750 ～ 1500 mg/d,Valsartan 80 ～ 160 mg/d, A Division horses Lin 100 mg/d, (2) control group, Valsartan 80 ～ 160 mg/d, Verapamil hydrochloride sustained-release capsules 180 mg/d, Aspirin 100 mg/d. (3) Blood pressure observation: Subjects in patients as early as 7: 00 and 22: 00 evening, measured two times a day and record systolic blood pressure blood pressure decreased significantly compared with those before treatment,4,6 weeks after the blood pressure weeks treatment their difference was significant (P<0.01), but the blood pressure has not dropped to normal ment review TC, TG, LDL decreased significantly after treatment, the difference was significant (P<0.05),HDL increased after treatment of (2.73±0.17), after treatment there was significant difference between improved (P<0.05), Verapamil treatment group was significantly better than the control group. Conclusion The combination of Verapamil and Metformin therapy for hypertensive patients with type 2 diabetes mellitus (DM) patients has good blood pressure lowering effect and blood glucose lowering effect. Key words: Verapamil ; Combined Metformin to trent; Hypertensive patients with Type 2 Diabetes Mellitus