Abstract
Objective To observe intravitreal ranibizumab injection combined with Ahmed valve implantation for reducing intraocular pressure (IOP) at different times. Methods Twenty eyes with neovascular glaucoma (NVG) whose IOP could not be controlled by medicine were chosen (9 cases in group A, whose economic condition was better, another 11 cases in group B), all the cases were injected with ranibizumab (Lucentis) 0.05 mL, after 1 week the Ahmed valve implantation were performed in group A, while group B were performed at 3-4 weeks. Then the FFA and the retinal laser photocoagulation treatment were taken promptly. Results The iris neovessels were exist in 1 case (group A) from 2 days to 7 days after the injection, while in group B were 2 cases. In group A: The IOP before injection was 35.0-51.5 (43.5±7.5)mmHg, 1 week after injection was 36.5-45.0 (40.5 ± 5.5)mmHg, 3 months after implantation was 14.5-21.0 (17.3 ± 2.5)mmHg, 6 months was 12.5-22.0 (16.0 ± 3.5)mmHg; in group B: The IOP before injection was 35.0-53.0 (44.5 ± 6.5) mmHg, 1 week after injection was 29.5-47.0 (37.0±5.6)mmHg, 3 months after implantation was 13.0-18.0 (15.0± 2.1)mmHg, 6 months was 14.5-20.0 (17.0±2.5)mmHg, there was no statistical difference (P >0.05) in two groups after implantation. In group A: anterior chamber disappearance happened in 2 cases, but no hyphema after implantation; group B: in the operation hyphema happened in 3 cases, and the anterior chamber disappeared in the next day, the visual acuity in 2 cases were decreased due to hyphema during follow-up period. In all the cases, the visual acuity in 14 cases was increased after implantation, unchanged in 5 cases. Conclusions There is no statistical difference about intravitreal ranibizumab injection combined with Ahmed valve implantation for reducing intraocular pressure (IOP) at different times, but it is suggested that implanting Ahmed valve as soon as possible for reducing complications. Key words: Neovascular glaucoma; Ahmed valve implantation; Ranibizumab
Published Version
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