Clinical efficacy of Jianpi Huashi Jiedu Decoction combined with opin suppository in treatment of patients with high risk HPV infection and cervicitis

Abstract

Objective To explore the clinical efficacy of Jianpi Huashi Jiedu Decoction combined with opin suppository for patients with high risk HPV infection and cervicitis. Methods A total of 77 high-risk HPV infection patients with cervicitis treated in our hospital from April, 2016 to March, 2019 were randomly divided into an observation group (38 cases) and a control group (39 cases). The control group was treated with opin suppository, and the observation group with Jianpi Huashi Jiedu Decoction and opin suppository. The clinical symptoms, HPV-DNA negative rate, and indicators related to immune function and inflammatory factors before and after treatment were compared between these two groups. Results The total effective rate of the observation group was higher than that of the control group (94.74% vs. 76.92%, P<0.05). The negative conversion rate of the observation group was higher than that of the control group (92.11% vs. 71.79%, P<0.05). The improvement rate of leucorrhea volume in the observation group was higher than that in the control group (94.74% vs. 76.92%, P<0.05). The improvement rate of purulence in the leucorrhea of the observation group was higher than that in the control group (97.37% vs. 79.49%, P<0.05). After the treatment, the levels of CD3+, CD4+, and CD8+ were higher in the observation group than in the control group [(59.12±7.97) %vs. (55.12±7.41)%, (28.89±5.18)% vs. (25.75±4.91)%, and (27.16±4.22)% vs. (24.68±4.58)%; all P<0.05) ], and were higher than those before the treatment in both groups. After the treatment, the levels of TNF-α, IL-6, and hs-CRP were lower lower in the observation group than in the control group [(16.16±3.31) pg/ml vs. (20.12±3.26) pg/ml, (21.88±3.33) pg/ml vs. (26.52±3.37) pg/ml, and (2.16±0.32) mg/ml vs. (3.68±0.28) mg/ml; all P<0.05], and were lower than those before the treatment in both groups. Conclusion Jianpi Huashi Jiedu Decoction combined with opin suppository in the treatment of cervical high-risk HPV infection and cervicitis has excellent therapeutic effect and has clinical reference value. Key words: Jianpi Huashi Jiedu Decoction; Opin suppository; High-risk HPV infection; Cervicitis