Clinical analysis of umbilical cord blood stem cell transplantation in the treatment of decompensated hepatic cirrhosis

Abstract

Objective To observe the clinical effect of umbilical cord blood stem cell transplantation in the treatment of decompensated hepatic cirrhosis .Methods The umbilical cord blood of healthy puerperal women was collected,and stem cells were isolated and injected into liver through hepatic artery to treat 20 patients withdecompensated＆nbsp;cirrhosis.Blood,liver function,coagulation changes ,indicators of clinical symptoms and adverse events were observed after transplantation 1 week,2 weeks,4 weeks and 8 weeks.Results 1 week after transplantation ,the fatigue,loss of appetite situation were improved in more than 80% patients,but the changes were not significant （ t=0.88,0.80, 0.20,0.23,0.56,all P〉0.05）.2 weeks after transplantation,the bloating of 60% patients was improved,ALB in-creased significantly（t=2.03,P〈0.05）.After 4 weeks,the bloating of 70%patients relieved,50%of patients with ascites subsided.ALB,ALT,PT were significantly improved （t=3.84,P 〈0.01;t =1.75,3.02,all P〈0.05）;8 weeks later,75%of patients with ascites subsided .Except for AST was not obvious ,other indicators were improved significantly（t=2.20,2.22,5.93,all P〈0.05）.Except for one case had low fever ,there were no other adverse reac-tions.Conclusion Cord blood stem cell transplantation in the treatment of decompensated cirrhosis can achieve a certain short-term treatment effects , especially in increasing the level of ALB and reducing PT , could resume liver damage and has relatively high security at the same time . Key words: Cord blood stem cells; Hepatic cirrhosis