Abstract

Objective To observe the short term effect of umbilical cord blood stem cell transplantation on liver fibrosis in patients with decompensated liver cirrhosis. Methods Sixty patients with decompensated liver cirrhosis underwent umbilical cord blood stem cell transplantation via hepatic artery into the patient’s body. The improvements in clinical symptoms were observed. The indexes of liver function and fibrosis were tested before transplantation and 2, 4, 8, 12 and 24 weeks after graft, respectively. Results The clinical symptoms, such as fatigue, abdominal distension, inappetence were improved to some extent. The serum alanine aminotransferase and type Ⅲ collagen in the patients decreased gradually from 4 weeks of transplantation and serum albumin level increased gradually, at 8 weeks from transplantation, the differences were significant(P 0.05). Conclusions Biochemical markers of liver fibrosis are improved in patients with decompensated liver cirrhosis after umbilical cord blood stem cell infusion. The best time to retransplantation may be 24 weeks from umbilical cord blood stem cell transplantation. Key words: Decompensated liver cirrhosis; Umbilical cord blood stem cell; Transplantation; Liver fibrosis

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