Cholinergic control of GABA release by carbachol at perisomatic inhibitory synapses in the CA3 region of mouse hippocampus

Abstract

Event Abstract Back to Event Cholinergic control of GABA release by carbachol at perisomatic inhibitory synapses in the CA3 region of mouse hippocampus G. G. Szabó1, N. Holderith1, A. I. Gulyás1, T. F. Freund1 and N. Hájos1* 1 Hungarian Academy of Sciences, Institute of Experimental Medicine, Hungary Action potential generation of hippocampal pyramidal neurons is controlled by perisomatic inhibition, originating from fast-spiking basket (FSBC)- and axo-axonic cells (AACs) as well as from regular spiking basket cells (RSBCs). These neurons play a role in feedforward and feedback inhibition and are tuned by cholinergic receptor activation. We aimed to clarify the impact of cholinergic receptor activation on synaptic communication between these perisomatic inhibitory neurons (PINs) and pyramidal cells (PCs). By performing paired recordings between the three types of PINs and PCs in mouse hippocampal slices, we investigated the release properties and their sensitivity to the cholinergic receptor agonist carbachol (CCh). Synaptic currents originating from the distinct types of PINs had different properties recorded in CA3 PCs. Analyzes of the decay kinetics suggested that at AAC-PC pairs synaptic cross-talk may occur between adjacent release sites. RSBCs showed robust asynchronous release, whereas the other two types of PINs did not. CCh decreased the GABA release significantly from all the three types of PINs to a different extent and via different receptor activation. In addition, CCh significantly reduced the short-term depression of synaptic transmission at FSBC- and AAC-PC pairs.These findings suggest that the contribution of different types of PINs to feedforward and feedback inhibition might be distinct that could be altered by cholinergic receptor activation. Keywords: Neurophysiology, Neuroscience Conference: 13th Conference of the Hungarian Neuroscience Society (MITT), Budapest, Hungary, 20 Jan - 22 Jan, 2011. Presentation Type: Abstract Topic: Neurophysiology Citation: Szabó GG, Holderith N, Gulyás AI, Freund TF and Hájos N (2011). Cholinergic control of GABA release by carbachol at perisomatic inhibitory synapses in the CA3 region of mouse hippocampus. Front. Neurosci. Conference Abstract: 13th Conference of the Hungarian Neuroscience Society (MITT). doi: 10.3389/conf.fnins.2011.84.00038 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 03 Mar 2011; Published Online: 23 Mar 2011. * Correspondence: Dr. N. Hájos, Hungarian Academy of Sciences, Institute of Experimental Medicine, Budapest, Hungary, hajos@koki.hu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers G. G Szabó N. Holderith A. I Gulyás T. F Freund N. Hájos Google G. G Szabó N. Holderith A. I Gulyás T. F Freund N. Hájos Google Scholar G. G Szabó N. Holderith A. I Gulyás T. F Freund N. Hájos PubMed G. G Szabó N. Holderith A. I Gulyás T. F Freund N. Hájos Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.