Abstract
Noncoding RNAs (ncRNAs) have recently been discovered to play a critical role in the onset and progression of cancer. Noncoding RNAs (ncRNAs) are proving to be the most exciting candidates which are being explored by the researchers across the world for therapeutic intervention as ncRNAs are turning up to be key biomarkers and regulators of cancer gene network. ncRNAs profiling and sequencing have revealed huge deregulation in human cancers because of aberrant mechanisms of ncRNAs biogenesis, amplification or deletion of miRNA genes, abnormal epigenetic, or transcriptional regulation. Dysregulated ncRNAs can be said to be the markers for cancer playing the role of oncogenes; however, the exact mechanism behind their role still needs to be explored in detail. In this chapter, we focus on various types of noncoding RNAs and their role as biomarkers for cancer. Finally, we discuss the relevance of ncRNAs in clinical practice by considering promises and challenges behind the bench-to-bedside translation.
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