Abstract
Mathematical models can approximate drug transport across microneedle-treated skin. Mathematical modeling of microneedle-based transdermal drug delivery normally entails the simulation of three coupled sub-domains i.e., microneedles, skin, and the blood circulation. Real or conceptual microneedle designs are converted into a computational domain before undertaking numerical simulation. Finite difference, boundary element, finite element and discrete element methods can be used for numerical modeling. In this chapter, the use of mathematical techniques for modeling microneedle-assisted drug delivery will be discussed.
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