Abstract
Metabolites have been used as biomarkers for many diseases. The development of highly sensitive and specific metabolite biomarkers may greatly enhance early detection rates, and the identification of potential new targets for therapy. Metabolic dysfunction is a common hallmark of the liver injury-related processes. In order to identify Jaundice syndrome-related biomarkers from urine metabolites, we investigated the specific metabolite profiles of Jaundice syndrome-related animal models by using combined ultraperformance liquid chromatography-mass spectrometry and pattern recognition approaches. This chapter (Parts I and II) introduces the concept of using metabolomics to explore metabolite profiling, and biomarkers analysis; by the establishment of Jaundice syndrome-related rat models induced by d-galactosamine, alcohol, alpha-naphthylisothiocyanate, and carbon tetrachloride. This study could provide insight into global metabolic changes and the mechanisms of pathology in Jaundice syndrome.
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