Abstract
Treatment of an ailment using combination therapy is rapidly gaining popularity as it provides the synergistic therapeutic effect of drugs, reduces individual drug related toxicity, and also represses the multidrug resistance via different mechanisms of action. The major bottleneck for developing a successful formulation for combination drugs is the poor aqueous solubility or low bioavailability of drug candidates. Recently, lipid based drug delivery systems have been used as a promising technology to address such challenges. These systems can be tailored for meeting the requirements of drugs or their products dictated by different diseases, their preferred routes of administration, cost, product stability, toxicity, and therapeutic efficacy. Combination lipid based drug delivery can provide sustained, controlled, and targeted delivery with enhanced therapeutic efficacy and reduced drug associated toxicity. This chapter highlights the advances in a combination approach using lipid based nanoparticles like nanoemulsion, solid lipid nanoparticles, nanostructured lipid carriers, and self- nanoemulsifying drug delivery systems. Emphasis has been given on the unique properties of these systems to design concerning efficacy, safety, and elucidate areas in which current therapeutic strategies can be improved.
Published Version
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