Abstract
Recently, advances in pharmaceutical research is focused on new delivery systems utilizing new devices to achieve modification of delivery time, targeting, as well as improve the in vivo solubility and hence bioavailability of poorly soluble drugs. Lipid based drug delivery systems (LDDS) consists of diverse group of formulations, each consisting of varying functional and structural properties that are amenable to modifications achieved by varying the composition of lipid excipients and other additives. LDDS has evolved, overtime, from micro- to nano-scale enhancing the efficacy and therapeutic application of these systems. LDDS are accepted, proven, commercially viable strategies for formulating challenging pharmaceutical molecules and can be tailored to meet a wide range of product requirements. Generally, most lipid drug delivery systems used as drug carriers have high stability, high carrier capacity, feasibility of incorporating both hydrophilic and hydrophobic substances and feasibility of variable routes of administration, including oral, topical, parenteral and pulmonary routes. LDDS can also be designed to allow modified drug release from matrices. LDDS could be broadly grouped into four: solid lipid particulate dosage forms, emulsion based systems, solid lipid tablets, and vesicular systems. Modifications from these four types include: lipospheres, solid lipid nanoparticles (SLNs), nano structured lipid carriers (NLC), lipid drug conjugate nanoparticles (LDC), self emulsifying formulations (SEFs), pickering emulsions, dry emulsions, micro and nano-emulsions, solidified reverse micellar solution (SRMS) based tablets, liposomes, herbosomes, cryptosomes and transferosomes amongst others. This work exhaustively reviewed the advances in LDDS and also drew comparison between the different types based on history, methods of manufacture, applications, advantages and disadvantages. Key words: Cryptosomes, lipospheres, lipoplexes, solid lipid tablets, pharmacosomes, virosomes, vesosomes.
Highlights
Pharmaceutical research is recently geared towards the development of new delivery systems of existing drugs (Dinesh et al, 2012)
The article reviews the newer lipid-based drug delivery systems utilized in formulating drugs in order to enhance their bioavailability, its applications, merits and demerits as well as comprehensive comparison among the Lipid based drug delivery systems (LDDS) were exhaustively discussed in order to guide formulation scientists in the choice of lipid based dosage form designs and selection
Gentamicin tablets have been produced by this method using lipid matrix based on solidified reverse micellar solutions consisting of phospholipid and triglycerides (Umeyor et al, 2012b) and the results show that solidified reverse micellar solution (SRMS)-based tablets containing gentamicin were successfully prepared by fusion melt-solidification method which is simple, reproducible, scalable and cheap (Umeyor et al, 2012b)
Summary
Lipid-based drug delivery systems (LDDS): Recent advances and applications of lipids in drug delivery. Lipid based drug delivery systems (LDDS) consists of diverse group of formulations, each consisting of varying functional and structural properties that are amenable to modifications achieved by varying the composition of lipid excipients and other additives. LDDS could be broadly grouped into four: solid lipid particulate dosage forms, emulsion based systems, solid lipid tablets, and vesicular systems. Modifications from these four types include: lipospheres, solid lipid nanoparticles (SLNs), nano structured lipid carriers (NLC), lipid drug conjugate nanoparticles (LDC), self emulsifying formulations (SEFs), pickering emulsions, dry emulsions, micro and nano-emulsions, solidified reverse micellar solution (SRMS) based tablets, liposomes, herbosomes, cryptosomes and transferosomes amongst others.
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