Abstract
Improving the efficiency and performance of a therapeutic molecule is among the most promising contributions of nanotechnology to the medical field. Nanomedicines offer multiple benefits for the treatment of chronic human diseases by multimodal, site-specific, and target-oriented drug delivery. Metallic nanoparticles (MNPs) due to their carefully controlled chemistry, small size and unique set of physical, chemical and photonic properties provide robust nanoplatforms for targeting the therapeutic agents. Additionally, integrating MNPs with targeting ligands or with different surface modifiers provides opportunity to increase bioavailability of the loaded drugs to the diseased tissues. In this perspective, the chapter outlines the major recent advances in the drug-delivery applications of metallic nanoparticles for improved performance both in vitro and in vivo. Design considerations and the underlying challenges with metal-based nanoparticles are also discussed. The fast, multimodal, and improved performance of the MNPs highlights their advantages as efficient carriers and therapeutic agents as well.
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