Abstract
Metabolic profiling and diagnosis biomarkers analysis of the GanYuPiXu (GYPX) Syndrome remains challenging. This chapter was undertaken to discover the potential biomarkers for the noninvasive early diagnosis of human GYPX. Urine samples were collected from GYPX patients. Metabolic profiling was performed by UPLC/MS combined with multivariate data analysis, and ingenuity pathway analysis that were both used to select the differential metabolites. As a result, 12 differential metabolites were identified involving several key metabolic pathways such as pentose and glucuronate interconversions, ascorbate, aldarate, cysteine, methionine, tyrosine, tryptophan, amino sugar, and nucleotide sugar metabolism. More importantly, of the 12 differential metabolites, four metabolite markers, prolylhydroxyproline, l-homocystine, alpha-N-phenylacetyl-l-glutamine, and 2-octenoylcarnitine were effective for the diagnosis of human GYPX, achieving a high sensitivity.
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