Abstract
This chapter addresses maternal epigenetic inheritance. It starts by introducing epigenetics and epigenetic reprogramming followed by reviewing the process of maternal epigenetic reprogramming. Subsequently, the responses of epigenetics to environmental exposure are discussed including external and internal environmental factors. This section includes the effects of pollutants, nutrition, assisted reproductive technologies, aging, noncommunicable diseases, and other aspects on epigenetic modifications. Also addressed are the maternal intergenerational and transgenerational inheritance of epigenetic alterations induced by environmental exposure and potential mechanism(s) mainly including the inheritance of DNA methylation, histone modifications, and noncoding RNAs. It further addresses the role of mitochondria in maternal epigenetic inheritance. Finally, perspectives of maternal epigenetic inheritance are addressed.
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