Abstract
The human gastrointestinal tract is colonized by a large number of diverse microorganisms that constitute the intestinal microecological system. Mutualistic intestinal microflora regulate a series of functions essential to life, including digestion and nutrient absorption, immune regulation, and biological antagonism. Disruption of the intestinal flora is closely associated with the occurrence and development of many human diseases. Therefore, it is critical to maintain a healthy intestinal microecological environment. Following oral traditional Chinese medicine (TCM) administration, human intestinal bacteria can metabolize or biotransform its active metabolites to increase their activities, facilitate their intestinal absorption, and detoxify substances that produce undesired side effects or toxicities. Aspects of synergistic TCM formulae compatibility can be established from the perspective of the intestinal flora metabolism. Similarly, ingredients found in TCM formulae can also regulate intestinal flora composition and protect intestinal mucosal barrier function so as to restore intestinal microecology homeostasis. Herein, we discuss gut microflora classification, the relationships between intestinal dysbacteriosis and disease, the important roles of gut microflora in TCM metabolism and the effects of TCM on modulating intestinal dysbacteriosis. Finally, future prospects for multiomics technique-based TCM mechanism of action studies are discussed.
Published Version
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