Abstract
Generally, there are hundreds and thousands of chemical compounds in one traditional Chinese medicine (TCM) formula. But only those that can be absorbed into the blood are the active ingredients of TCM, according to serum pharmacochemistry theory. Based on our previous serum pharmacochemistry study, 23 protype components and seven metabolites from the Shexiang Baoxin Pill were detected in rat plasma, including eight gensinosides, five bufadienolides, four cholic acids, and six volatile compounds among those protype components. As the physicochemical characteristics of these plasma-absorbed compounds varied greatly, their in vivo pharmacokinetics (PKs) properties, such as the absorption speed, tissue distribution, and metabolism differences, were different from one another. In this chapter, the PK characteristics of gensinosides, bufadienolides, and four volatile compounds were studied to explain the in vivo process of these main active compounds of the Shexiang Baoxin Pill as an important guarantee for safe clinical use.
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