Abstract
Topical drug delivery is considered as the first option in the treatment of eye diseases. But, the unique anatomical structure and physiological functions of the eye restricts entry of drugs to target sites in the eye. In addition, dynamic and static ocular barriers also diminish drug absorption through intra ocular tissues. Thereby, topical administration of drugs via conventional dosage forms mostly result in low ocular drug bioavailability as well as the necessity of frequent dosing and low patient compliance. As another approach, intravitreal injections are applied to deliver drugs into the posterior segment of the eye, but this application causes serious side effects such as retinal detachment or hemorrhage in the eye. Periocular injections also have side effects such as high intraocular pressure, cataract development, and corneal decompensation.
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