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Abstract
Vitamin D has a role in preventing diseases of human aging, including age-related macular degeneration (AMD). Age-related macular degeneration is the principal cause of registered legal blindness among those aged over 65 in the USA, Western Europe, and Asia. The etiology and pathogenesis of AMD are still unknown. However, studies have suggested that vitamin D could delay the progress of AMD. Vitamin D3 improves retinal function through reducing inflammation, reducing the number of activated macrophages, and clearance of amyloid-beta deposition. The exact process by which vitamin D protects against AMD is unknown, but putative mechanisms that arise at the molecular and cellular levels are reviewed in this chapter. Therapeutic strategies to improve vitamin D status in the individual, with the ultimate aim of ameliorating the onset of AMD, are also reviewed.
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