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Abstract
Lycopene, a naturally occurring red carotenoid pigment found in tomatoes, pink grapefruit, watermelon, and other fruits, is associated with many beneficial effects on human health. In the human eye, lycopene is present in the retinal pigment epithelium (RPE)-choroid, ciliary body, and iris. The suppressive capability of lycopene on oxidation, inflammation, angiogenesis, and cell proliferation and migration has been shown for multiple cell types. In this chapter, these effects of lycopene and its derivatives are summarized, with a focus on in vitro studies. Furthermore, the molecular mechanisms behind the actions of lycopene on human RPE cells, and the potential beneficial effects of lycopene in the prevention and treatment of age-related macular degeneration and proliferative vitreoretinopathy, are discussed.
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