Abstract
Peptide drugs are a unique class of pharmaceutical agents involved in a wide range of therapeutic areas, including urology, respiratory, pain, oncology, metabolic, cardiovascular, and antimicrobial applications. More than 80 peptide drugs have been approved and marketed worldwide. A lot of them mimicked their initial natural sources, such as natural hormones and natural bioactive peptides from bacteria, fungi, plants, and animal, or had the same structure. Since 2000, peptide drug development has entered a new era as a result of technological advances in structural biology, recombinant biologics, and synthetic and analytic technologies. Peptide drugs are no longer simply hormone mimics or composed simply of natural amino acids. This chapter summarizes and discusses the structures, modifications, and biological functions of peptide drugs approved since 2000.
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