Abstract
The development of peptide drugs has become a global concern due to their merits such as high biological activity, low medicinal dose and easy to industrialization. However, low enzymatic stability, short half-life and low tissue permeability hamper the clinical application of nature peptide drugs. In order to overcome the bottlenecks, we developed a series of new modified strategies. By applications of these strategies, we wish to accelerate the pace of the development in clinical application of peptide drugs.
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