Abstract
Quassinoids, originating from the oxidative degradation of tetracyclic tirucallane triterpene, are a diverse class of secondary metabolites identifies from nature mostly in the Simaroubaceae family. The crucial pharmacologic activities and structural complexity of quassinoids have long fascinated scientists owing to their medicinal use, infamous toxicity, and unique biosynthesis. So far, 482 quassinoids, assigned to six skeletons, have been isolated and identified from plants. The names, classes, molecular formulas, and plant sources of these secondary metabolites are discussed here and their applications for the research of antitumor drugs are summarized.
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