Abstract
Vaccines have been used as a preventive modality against infectious disease for a long time. The application of vaccines to treat the diseases, which have interactions with the immune system, have revealed a new concept of immunotherapy, known as therapeutic vaccines. Many efforts have been made to utilize this modality in the most efficient way. To optimize the current vaccines, understanding the determinants such as selection of the appropriate antigens, combination of effective adjuvants, application of a delivery system, and administration through the proper route are necessary. In this chapter, we will discuss the mentioned determinants to prepare the background for extending the knowledge of vaccinology.
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