Abstract
Laboratory rats are widely used in neuroscience-related research and there are numerous rat models of human nervous system disorders. These include mental illnesses such as anxiety, depression, posttraumatic stress disorder, neurodegenerative diseases such as Alzheimer's and Parkinson's diseases, and models of acute and chronic pain. Most rat models of these diseases require an intervention, such as an early life stress paradigm or a drug or toxin treatment to disrupt the function of specific neurons or pathways. Using the rat models, it is possible to identify the specific neurons and brain pathways affected in these disorders or diseases and to develop and test new and more effective treatments. There are few rat models that involve genetic interventions but with the development of CRISPR/Cas9 technology it is likely that there will many new rat models of human diseases in the near future.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
