Abstract
Over the past decade there has been a wealth of resources, tools, and techniques developed for the rat. The availability of the rat genome sequence and the ability to do site-specific genome editing allows researchers to rapidly and accurately link biology to genome. Available gene expression data sets for dozens of commonly used rat strains across many tissues at different ages, and for male and female rats, add enormous power to the reference assembly and annotations. Well-characterized rat strains and panels of strains are providing the foundation for building models for precision medicine and systems genetics for complex traits. Bioinformatics resources, such as the Rat Genome Database, integrate gene, trait, pathway, disease, and drug/chemical interactions and provide software tools for analysis.
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