Abstract
Successful treatment of pathologies affecting eye depends on inherent activity of the drug, its ability to cross several ocular barriers in order to reach biophase and most importantly its maintenance in the biophase for prolonged period. The present chapter on ocular drug delivery system (ODDS) gives an insight on different types of ocular dosage forms, ranging from simple sterile eye drop for the ocular surface to complex implants for intraocular tissue, meant for instilling, administering or delivering drug to eye. The different barriers which these delivery system needs to surmount, had been discussed briefly with insights on different types of commercially available simple and complex ocular formulations. Advancement in traditional ocular delivery system with emphasis on minimizing precorneal losses using bioadhesives or penetration enhancers and advanced corneal delivery systems like nanoparticulate systems, liposomal delivery systems, iontophoresis-based devices, punctal plugs, nano implants, etc. had been also discussed. An overview of recently patented formulations, meant for ocular pathologies that are not amenable to topical drug delivery, are also highlighted to stimulate further research in the unexplored arena of ocular drug delivery. This concise information on current research and development efforts in the area of ocular delivery will be of tremendous help to design better therapeutic systems for various ailments and disorders affecting eye.
Published Version
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