Abstract
Implantable drug delivery systems (IDDS) allow for reduced medication doses that decrease the systemic side effects associated with oral, transdermal, or parenteral drug delivery routes. Localized and controlled drug delivery helps maintain the drug concentration within the therapeutic window and improves patient compliance by the limitation of repeated and timely intake of medication. The chapter focuses on the IDDS technology, considering fixed-rate, programmable, osmotic, or other microsystem-based implantable pumps. Detailed descriptions of the infusion mechanisms, their evolution, and performances are provided together with the remaining challenges. Some of the most recent and promising implantable drug delivery systems are also introduced.
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