Abstract
Curcuma longa L., colloquially known as turmeric or Indian saffron in English, is an important spice and a medicinal plant in the various traditional and folk systems of medicine in India. Turmeric is widely used for treating various ailments, and scientific studies have validated many of the ethnomedicinal claims and observations. Preclinical studies have shown that turmeric and its principle compound curcumin are effective as a gastroprotective agent in various models of gastric ulcerations like in pylorus ligation, indomethacin, reserpine, and hypothermic-restraint stress. In vitro studies have shown that curcumin was effective on the bacteria Helicobacter pylori infection, a group I carcinogen and an etiological agent for peptic ulcers. However, clinical studies performed with limited number of patients have been contradictory. The current review summarizes the observations for the gastroprotective effects and the mechanisms responsible for this property.
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