Abstract
Oxidative alterations of the male gamete have long been known to affect its structures and functions leading to situations of infertility. In this chapter, we bring into focus how and why oxidative damage is such a sensitive issue for spermatozoa. In addition, we emphasize recent data showing how sperm nuclear and DNA oxidative alterations are particularly important. We discuss the fact that sperm chromatin and DNA oxidative damage might be at the origin of genetic and epigenetic defects. These could impair the developmental program after fertilization as well as effecting next generations. Finally, we discuss the potential value of antioxidant therapeutic approaches that could be used in a clinical context to relieve some of the paternal damage.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Oxidants, Antioxidants, and Impact of the Oxidative Status in Male Reproduction
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
