Abstract
Poly(lactic-co-glycolic acid) (PLGA) has been well known one of polymer as a material of drug delivery system. In particular, previous studies reported that microspheres or nanoparticles prepared with PLGA maintained the stability of the encapsulated drug and enabled regulation of drug release. Recently, we have shown that PLGA, a biocompatible, biodegradable, hydrophobic polymer, can be conjugated to various hydrophilic drug molecules, including oligonucleotides or peptides. When this hydrophobic PLGA was directly conjugated to various hydrophilic molecules such as oligonucleotide or peptides, the resultant drug–PLGA conjugates (drug–PLGA hybrid) spontaneously formed nanoparticles or self-assembled into micelles. In this chapter, we introduce our results and other research about drug–PLGA hybrid micellar systems as an unprecedented PLGA-based formulation design. These results suggest that the novel PLGA micellar system could be useful in the development of cancer therapeutics or nucleic acid–based medicine.
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