Abstract
Metabolomics is concerned with the comprehensive assessment of small molecule metabolites in biological systems, and provides both a powerful approach and insight into the mechanisms of diseases. Type 2 diabetes (T2D) (a manifestation of Xiaoke Syndrome) is called the burden of the twenty-first century, and is growing at an epidemic rate. We applied the urinary metabolomics approach to discover, and characterize the differentiating metabolites, to explore metabolic pathways in an experimental model for high-fat diet induced T2D. Six differential metabolites were found in the negative mode, and involved the key metabolic pathways linked to pentose and glucuronate interconversions, starch, sucrose metabolism, and tyrosine metabolism. And subsequently the metabolomics technology was applied to investigate the changes of urinary metabolite levels in T2D rats, after having been treated with the Tianqi Jiangtang Capsule (TJC). The majority of these metabolite levels were interestingly restored to that of the healthy rats post-TJC treatment.
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