Abstract
This chapter discusses reserpine that has a mammotropic and lactogenic effect in rats, rabbits, and women. The endocrine effects of reserpine are well known. They are mediated by the hypothalamus. The dissociation between the mammotropic and sedative effects of tranquilizers is possible, both being caused by independent mechanisms. The results furnish an interesting example for the SAR between closely related chemical compounds, comparable to earlier results with phenothiazine derivatives. The reserpine and most of its derivatives have a strong lactogenic effect. The absence of all lactogenic effect in methoserpidine is particularly interesting because it differs from the highly lactogenic reserpine only in that the methoxy group is shifted from C 11 to C 10 . Studies on the SAR of reserpine analogs supply further evidence for a possibility of complete dissociation between the mammotropic and sedative activities of hypothalamic tranquilizers.
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