Abstract
The effect of growth hormone on DNA synthesis in rat cartilage and adipose tissue was studied, and its activity was compared with that of human placental lactogen. The treatment of hypophysectomized rats with growth hormone greatly increased in vitro incorporation of thymidine in costal cartilage and epididymal adipose tissue. Growth hormone also caused a modest increase of thymidine incorporation in adipose tissue from normal rats. Fasting diminished incorporation of thymidine in normal rat adipose tissue, and growth hormone partially prevented the decrease. Human placental lactogen was much weaker than growth hormone in stimulating thymidine incorporation in rat cartilage or adipose tissue. The maximal effect of placental lactogen was of the order of 10% of the effect of growth hormone. (Endocrinology 83: 645, 1968)
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