Abstract

Heart failure is a disease of multifactorial etiology and complex treatment. Despite the clinical improvement seen with current treatment, the prognosis of patients with heart failure is poor. In recent years, the use of stem cells in cardiac diseases has been widely studied. Of the various cell types studied, mesenchymal stem cells (MSCs) have shown immense promise in heart failure therapy. Phase 1 and 2 trials have demonstrated safety of MSC therapy and have suggested improvements in clinical and cardiac remodeling parameters. The use of MSCs in the treatment of heart failure may eventually be an important tool in the therapeutic options for these patients.

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