Abstract
Plant polysaccharides such as pectin, cellulose, starch, and gums have been used as excipients in the pharmaceutical industry due to being molecules recognized as nontoxic, biodegradable, and exhibiting unique physicochemical properties. Films, tablets, gels, and nanoparticles are included as dosage forms intended for buccal drug delivery purposes. Nevertheless, buccal drug delivery is complicated due to the salivary flow that shortens the residence time of dosage forms when applied. Current research in this field is focused on studying mucoadhesive polymers as excipients for increasing drug retention at the buccal mucosa. In this chapter, the use of plant polysaccharides in buccal drug delivery is reviewed, mainly focusing on mucoadhesive plant polysaccharides and starting by explaining the buccal dosage forms, the buccal mucosa tissue, and theories for polymers mucoadhesion.
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