Abstract
Stimuli-responsive amphiphilic block copolymers can self-assemble in aqueous media into nanosized polymeric micelles (PMs). Biocompatible PMs have been demonstrated to be excellent nanocarriers for the successful release of drugs, genetic materials, and imaging agents for the diagnosis and treatment of various diseases. To date, a wide range of internal (pH, redox, enzyme) and external (temperature, light, magnetic) stimuli–responsive PMs with excellent physicochemical and targeting capabilities have been reported. Among internal stimuli–responsive PMs, enzyme-responsive PMs are unique for their controlled delivery of various therapeutic agents, and the integration of responsive polymers with enzyme-catalyzed reactions enhances triggering selectivity and specificity. This chapter briefly summarizes the various synthesis strategies of enzyme-responsive PMs and promising applications in controlled drug delivery and diagnostics.
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