Abstract
Tumor metastasis is a complex process by which cells disseminate from their primary site and form secondary tumors at a distant site. Although the mechanisms underlying this multistep process remain to be fully determined, the developmental program epithelial–mesenchymal transition (EMT) has recently been attributed to promoting carcinoma invasion and metastasis. In this chapter, we focus on the EMT program and its malignant phenotypes associated with metastasis in several different cancers, as well as key fundamental players including circulating tumor cells, disseminated tumor cells, and cancer stem cells. Metastasis is the major cause of death in the vast majority of cancer patients, and thus a better understanding of the role of these key players will undoubtedly lead to the discovery of much-needed therapeutic interventions targeting metastasis.
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