Abstract
Cancer cells within tumors differ in phenotype, genetic and epigenetic modifications and functions. In an increasing number of tumors, a proliferative hierarchy has been defined where a subpopulation of cells possesses self-renewal potential, similar to the somatic stem cells of the organ from which they arise. The so called “cancer stem cell's (CSCs)” unique ability to perpetually maintain tumor growth is, in part, due to a complex balance of high expression of self-renewal genes and low expression of differentiation genes. State-of-the-art strategies based on single-cell analysis to identify novel self-renewing genes as well as assays to test their long-term proliferation potential are in development due to the promise of revealing novel therapeutic drugs that will specifically target the self-renewal properties of CSCs.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
