Abstract
The hallmarks of cancer stem cells (CSCs) are self-renewal, tumor propagation, generation of heterogeneous progeny, and therapeutic resistance. Better understanding of CSC biology would provide insights on how to overcome major obstacles encountered during the course of cancer treatment such as resistance to therapy and distal metastasis. Studying CSCs needs special consideration given they represent a minor fraction of the tumor cell population and they dynamically transit out of the stem cell–like state. In this chapter we will describe various methods to investigate and enrich for CSCs. We will also discuss the importance of utilizing multifaceted approaches based on various principles to tackle different aspects of CSC biology.
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