Abstract
ECO/siRNA nanoparticles and breast cancer metastasis.
Highlights
Metastasis is often referred to as “The Last Frontier in Cancer Research” due to the cellular, molecular, and genetic complexities associated with this malignant behavior
To test the aforementioned hypothesis, we exploited the central importance of β3 integrin as a master regulator of epithelial-mesenchymal transition (EMT) programs and metastasis in triple-negative breast cancers (TNBCs) [2]
We speculated that the necessity of TNBCs to upregulate their expression of β3 integrin as they transition through and complete EMT programs would provide a targetable marker to “treat” metastatic TNBCs in a preclinical therapy model
Summary
Metastasis is often referred to as “The Last Frontier in Cancer Research” due to the cellular, molecular, and genetic complexities associated with this malignant behavior. We loaded ECO-based nanoparticles with siRNA against β3 integrin (ECO/siβ3), whose subsequent administration to human and murine TNBCs abrogated their expression of β3 integrin, and inhibited their acquisition of EMT and invasive phenotypes, as well as their growth in 3D-culture systems [3].
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