Expressions of integrinβ1 and p73 in triple negative breast cancers and its clinical significance

Abstract

Objective To study the expressions of integrin β1 and p73 in triple negative (ER-、PR-、HER2-) breast cancers and evaluate its clinical significance, exploring the relationship between clinicopathological parameters. Methods The immunohistochemistry SP methods was used to evaluate the expression of integrinβ1 and p73 in 93 cases of triple negative breast cancer,58 cases of none triple negative breast cancer. The correlation of integrinβ1 and p73 exprssion with clinicopathologic characteristics and between the two proteins were analyzed. Results The expression of integrinβ1 in the triple negative breast cancers was significantly higher than those of none triple negative breast cancer(83.87% vs 67.24%), with a significant difference(χ2=5.66,P=0.017). The expression of p73 in the triple negative breast cancers was significantly higher than those of none triple negative breast cancer (65.59% vs 46.55%), with a significant difference(χ2=5.33,P=0.021). In triple negative breast cancers,integrinβ1 expression was associated with axillary lymph node metastasis(χ2=6.206,P=0.021)and TNM stage(χ2=4.854,P=0.041), but it was not correlated with patients age(χ2=0.121,P=0.783), tumor size(χ2=1.402,P=0.271)and histologic grade(χ2=1.042,P=0.376). p73 expression was associated with histologic grade(χ2=5.503,P=0.020),axillary lymph node metastasis(χ2=4.626,P=0.047)and TNM stage(χ2=5.828,P=0. 024), but it was not correlated with patients age(χ2=0.858,P=0.387), tumor size(χ2=0.875,P=0.388).Correlation analysis showed that integrinβ1 expression was positively correlated with p73 expression in triple negative breast cancers(r=0.359,P=0.000). Conclusions p73 has its tissue specificity, both integrinβ1 and p73 protein may participate in the development of triple negative breast cancers, and could serve as an important potential marker in the aspect of invasiveness and metastasis in triple negative breast cancers. Key words: breast neoplasms; Triple negative; immunohistochemistry; integrinβ1; p73