Abstract
Over the last decade, chiral liquid chromatography has made tremendous advances in selectivity and efficiency. These developments have been beneficial to many scientific disciplines especially in the field of high-throughput research. In this chapter, we review the fundamentals of chiral separations, classes of stationary phases, new particle morphologies, bonding chemistry of chiral selectors and high-efficiency packing procedures. Special detectors for enantiomeric separations are surveyed. The latest developments in chiral chromatography have culminated in sub-second separations of enantiomers. Instrumental considerations to achieve ultrafast enantiomeric separations are discussed. Unique applications of chiral chromatography such as shape selectivity, formation of “Batman” peaks, peak shapes under overloading conditions, and future developments are highlighted.
Published Version
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