Abstract
The development of a practical approach determinining the absolute configuration of natural and artificial molecules is a challenge in the life and material sciences fields. Exciton-coupled CD (ECCD) method is a powerful tool for determination of the stereochemistry of chiral molecules in a non-empirical manner. We have developed chiroptical probes based on biphenyl chromophores. Covalent- and noncovalent-bond formation between the probes and the substrate molecules can effectively transcribe the chiral information of the substrates into a spatial arrangement of the chromophores. Exciton-coupling between the chromophores gives rise to two split CD Cotton effects in the UV region. From the signs of the Cotton effects, the absolute configuration of the substrates is determined. Here, we will report the design and the application of the chiroptical probes.
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