Abstract
Current techniques for chiral resolution and analysis such as high-performance liquid chromatography, X-ray crystallography, and chiroptical spectroscopy are time consuming, expensive, or low fidelity. Recently, we have experimentally validated the existence of a molecular propeller effect and demonstrated both chiral separation and absolute configuration determination. The propeller effect, as a hydrodynamic phenomenon, does not rely on specific interactions with a chemical matrix and therefore the direction and velocity of translational motion for any new chiral molecule can be reliably determined using theoretical modeling, thus providing a priori information about expected performance, as well as enabling the assignment of absolute configuration. In this chapter, we describe how molecular propeller effect can be used for chiral separation and analysis.
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