Abstract
The eye is the most delicate organ of the body, and it is essential for vision; thus it is critical to administer the drugs via this route safely. The biggest challenge in ocular therapies is achieving and maintaining a sufficient quantity of the drug at the site of action for an adequate period. The conventional forms of the drug (eye drops, suspensions, and ointments) have very low bioavailability and a short residence period in the ocular zone due to physiological (tear turnover, nasolacrimal drainage, tear proteins, melanin binding, drug-metabolizing enzymes, etc.) and anatomical barriers (corneal epithelium, stroma, blood–aqueous barrier, conjunctival blood and lymph flow, and tear drainage). Biocompatible and biodegradable polymers have been employed in the formulations of ocular drugs to address these problems. These polymers help in controlling the drug release, promote drug penetration, and also help in targeting. In this chapter, we discuss the significance and applications of plant-derived polysaccharides in ocular drug delivery.
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