Abstract
The chapter primarily studies the error introduced by a heterogeneous tracer distribution within a particular tissue component assumed to be homogeneous. It compares two different approaches: (1) a pixel-based method (PIX-PVC), which is a successive elimination-substitution method that yields corrected tissue maps, and (2) a region-of-interest-based technique (ROI-PVC), which is a direct method of solving a system of simultaneous linear algebraic equations. The application of the PVC methods to real data does not allow favoring of one method over the other, although ROI-PVC seems to provide more consistent estimates. ROI-PVC is easier to implement in the case of more heterogeneous tracer distributions, because it does not require any priori knowledge of tracer levels, as is the case for PIX-PVC..
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